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Boost Your Gut Health on GLP-1: How Akkermansia, Colostrum & Fiber Gummies Work Together 

Woman holding stomach to support digestive health while on GLP-1 medication
Posted in Life Style, Weight Loss

Boost Your Gut Health on GLP-1: How Akkermansia, Colostrum & Fiber Gummies Work Together 

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GLP-1 medications have transformed how we approach weight management and metabolic health, but their effects don’t end there. These medications may create changes in your gut microbiome that can be challenging as your body adapts to treatment but can also be manageable with the right knowledge and support.

It’s important to understand why digestive changes happen while using GLP-1 medications. From initial nausea to ongoing constipation, recognizing how your treatment affects gut health can help you manage symptoms more effectively and feel more in control of your wellness journey.

How GLP-1 Medications Impact Gut Health

Most patients notice GLP-1 medications affect appetite shortly after beginning treatment, but research shows that these medications also trigger more complex changes throughout your digestive system.  

Beyond appetite changes, GLP-1 medications may change the types and amounts of bacteria living in your digestive system. These changes happen because the GLP-1 medications slow down how quickly food moves through your stomach and alter the environment inside your gut, including acid levels and the nutrients available for bacteria to feed on. 

Over time, these shifts in gut bacteria, including increases in beneficial bacteria like Akkermansia muciniphila and Bacteroides, can play a role in both the positive effects of treatment and some of the digestive side effects patients may notice.

Understanding GLP-1 Digestive Effects and When They Occur

If you’re taking a GLP-1 medication, you’ve likely noticed some digestive changes along the way. Nausea, constipation, and stomach discomfort are common side effects that some people may encounter, especially during the first few months of treatment. Although these effects usually improve with time, they’re one of the main reasons many people seek extra support for their gut health during their GLP-1 journey.  

These digestive effects happen because GLP-1 medications work throughout your entire digestive system, slowing how quickly food moves through your stomach and intestines. This is one of the key ways GLP-1 medications provide their appetite and blood sugar benefits. However, when food moves more slowly, it can lead to constipation and irregular bowel movements. Nausea can also occur as your body adapts to these changes.

Understanding that digestive symptoms are a normal part of how GLP-1 medications work can be reassuring, but you don’t have to just endure them. Many patients find that targeted digestive support makes this adjustment period easier, helping them stay consistent with treatment while their body adapts.

That’s why supporting overall wellness during GLP-1 therapy usually involves addressing multiple aspects of health at the same time.

Supporting Your Gut Microbiome During GLP-1 Therapy

Studies show that the mix of bacteria in your gut may play a role in how well GLP-1 medications work. In fact, people with higher levels of certain ‘good’ bacteria sometimes see better results from treatment.

Because of slowed digestion, GLP-1 medications may encourage the growth of helpful gut bacteria, like Akkermansia muciniphila. They may also help your gut lining stay strong, support the natural compounds your body makes during digestion, and reduce bacteria linked to inflammation and metabolic problems. These bacterial shifts don’t happen overnight, though. Like most changes in the body, your gut microbiome adjusts gradually.  

Targeted nutritional support can help manage these changes that can happen in your gut while taking a GLP-1 medication. For example, the foods you eat can play a big role in keeping your gut bacteria balanced while you’re on GLP-1 treatment. Foods high in fiber, like fruits, vegetables, beans, whole grains, nuts, and seeds, give your good gut bacteria the food they need to grow. Fermented foods, such as yogurt, kefir, sauerkraut, and kimchi, can add more good bacteria to your system and help keep things in balance.

Cutting back on processed foods and added sugars also makes it harder for harmful bacteria to grow. These simple healthy habits can help your gut stay balanced and work together with the benefits of GLP-1 medications.

Targeted Supplements to Support GLP-1 Therapy

Akkermansia for Digestive and Metabolic Support on GLP-1

Akkermansia muciniphila is a beneficial bacterium that’s become important in gut health research. It naturally lives in healthy digestive systems and helps keep your gut lining strong while supporting healthy blood sugar levels. 

What’s interesting about Akkermansia is that it produces a protein called P9, which signals your body to make more GLP-1 on its own. This means that increasing Akkermansia in your gut could help boost your body’s natural GLP-1 production and support better metabolic health. 

Ivim Health’s Akkermansia supplement combines this beneficial bacterium with a small amount of inulin, a prebiotic fiber that acts like food for good bacteria. The inulin helps create the right environment for Akkermansia and other beneficial bacteria to thrive. This combination shows how probiotics (the actual bacteria) and prebiotics (their food source) work as a team in your gut. 

For people on GLP-1 therapy, adding an Akkermansia supplement could be a natural fit, since GLP-1 medications can help promote beneficial gut bacteria. It may help support the positive changes that are already happening in your gut and could therefore help reduce digestive side effects while supporting your long-term metabolic health goals.

Digestive Support During GLP-1 Therapy: The Role of Colostrum

While colostrum is best known as the nutrient-dense ‘first milk’ for infants, it actually has benefits that could extend to adult digestive health. This natural substance is packed with growth factors and protective compounds that may help support your digestive lining. That makes it particularly valuable during periods when your digestive system is adjusting, like what happens when you start GLP-1 therapy. 

Ivim Health’s Colostrum Complex comes as an easy-to-mix orange-flavored powder that’s specifically designed to support your digestive system while you’re adjusting to GLP-1

medications. The formula combines grass-fed bovine colostrum with L-glutamine, an amino acid that helps nourish your gut cells and can help maintain a healthy digestive lining during this transition. We’ve also added turmeric extract to help support your body’s natural inflammatory response and prebiotic fiber to feed the beneficial bacteria in your gut. 

The powder format gives you flexibility in how and when you take it, you can mix it into smoothies, water, or whatever beverage works best for you. This is especially helpful if you’re dealing with nausea from your GLP-1 medication, since you can adjust when and how you take it based on how you’re feeling each day.

Supporting Digestive Comfort on GLP-1’s With Prebiotic Fiber

Fiber supplementation may offer several advantages for people using GLP-1 therapy: it can help promote regular digestion, help maintain healthy blood sugar levels, support feelings of fullness, and nourish beneficial gut bacteria. These effects work together with your medication and may enhance your overall results. 

Ivim Health’s Fiber+ gummies offer you a gentle, convenient way to support your digestive health in a pleasant-tasting form. They can help you maintain consistency with your treatment while your body adjusts.

If you’re experiencing irregularity while adjusting to your GLP-1 medication, these gummies can be particularly supportive. They’re easy to take with you anywhere, and you can start with just one gummy and gradually work up as your body adapts.

Understanding Synergistic Support for GLP-1 Therapy

These supplements were designed to work together to support your digestion while your GLP-1 medication does its job. Akkermansia with inulin may help encourage the growth of beneficial gut bacteria, the colostrum complex can support your gut lining as your body adjusts, and prebiotic fiber, provides fuel for good bacteria while helping to promote regularity. 

Research suggests that people with a healthy mix of gut bacteria may respond better to GLP-1 medications. When your gut is balanced, it produces helpful compounds like short-chain fatty acids and bile acids that can enhance how GLP-1 medications work. A healthy gut also helps keep inflammation in check, supports better blood sugar control, and may strengthen the feeling of fullness that GLP-1 medications provide. This is why supporting your digestive health isn’t just about comfort, it may actually help your medication work more effectively.

A Holistic Approach to GLP-1 Wellness

Digestive support represents just one piece of your overall wellness puzzle during GLP-1 therapy. Understanding how different aspects of health work together can help you feel your best throughout your weight loss journey. 

Quality sleep plays a crucial role in digestive health and can influence how well your body processes the changes happening during GLP-1 treatment. Poor sleep can affect gut bacteria balance and may worsen digestive discomfort, while restorative sleep and proper sleep hygiene support your body’s natural adaptation processes. 

Staying properly hydrated becomes even more important when your digestive system is adjusting to medication effects. Adequate hydration supports digestive function, helps with any fiber supplementation you might choose, and can help minimize some GLP-1 side effects. Effective hydration for cellular health involves strategies that go beyond just drinking more water. 

Keeping your muscles strong while losing weight can support day-to-day functions and

overall wellness. Making sure your body gets enough amino acids and minerals may help support muscle maintenance, metabolic health and can make it easier to stick with GLP-1 treatment. 

For those looking for more complete support, personalized medical care that combines GLP-1 therapy with hormone balance can offer insights into a whole-body approach to long-term wellness. 

The key is recognizing that digestive comfort, quality sleep, proper hydration, and muscle support all work together to help you feel your best during your GLP-1 treatment.

Comprehensive GLP-1 Therapy Support: The Ivim Health GLP-1 ID Program

While individual supplements can help target specific needs, a comprehensive medical program can provide a more complete approach to getting the most from GLP-1 therapy. Side effect mitigation is an important tool, but a program that aims to decrease side effect frequency can be even more helpful.  Ivim Health’s GLP-1 ID (Individualized) program goes beyond supplements to coordinate comprehensive medical care. We know that successful GLP-1 treatment involves more than just the medication itself.

What the GLP-1 ID Program Includes:

The GLP-1 ID program includes personalized medical evaluation and prescription management, with individualized dosing of compounded semaglutide or compounded tirzepatide based on your specific response and tolerance.  

Ongoing medical monitoring throughout your treatment emphasizes safety and effectiveness, while the Ivim Health App provides convenient tracking and communication with your care team. 

Beyond medical support, the Ivim Healh GLP-1 ID program integrates coaching and community support, as well as formulated supplements as part of a coordinated care approach. 

Ivim Health’s published clinical study found that patients lost an average of 46% more weight over 68 weeks with comprehensive care protocols. Our GLP-1 ID program applies these learnings by combining individualized GLP-1 dosing with ongoing medical guidance, personalized support, and resources designed to help patients manage side effects, stay consistent with treatment, and build sustainable habits for long-term health. 

This comprehensive approach shows how addressing multiple aspects of your health can lead to better treatment results. The program provides compounded medications, with doses adjusted based on your specific needs and treatment response, maximizing GLP-1 therapy success with digestive and metabolic support 

Supporting your digestive health can make a real difference in your GLP-1 therapy experience. By helping your gut bacteria thrive and easing the common digestive challenges you may face, targeted supplements like Akkermansia, colostrum, and fiber can help you adapt more comfortably to treatment. Starting slowly, staying consistent, and working with a healthcare provider helps to ensure your approach is tailored to your unique needs while supporting your overall gut and metabolic wellness. 

Take control of your GLP-1 journey by supporting your digestive and metabolic health. Our GLP-1 ID Program provides you with personalized dosing to help you stay on track, while our targeted supplements for digestive and metabolic support can complement your therapy. If you’re also looking to support hormonal balance as part of your overall wellness, explore our Women’s Hormone Optimization Program. 

Ivim Health provides you with expert support, personalized care, and all the resources you need to feel confident and supported every step of the way. 

Reviewed by Courtney Floyd, MD, Physician with Ivim Health

Disclaimer: This information is for educational purposes only and does not constitute medical advice. Always consult with qualified healthcare providers before starting any weight management or diabetes medication. This information is provided for educational purposes only. Individual results may vary. The products in this article are not intended to diagnose, treat, cure, or prevent any disease.  

Compounded medication is not FDA-approved. Compounded drugs have not undergone FDA review for safety, efficacy, or quality. Use only as directed by a licensed healthcare professional.    

Clinical Study Disclaimer: *Based on Ivim’s published study, Ivim patients following the Ivim Protocol lost an average of 46% more weight over 68 weeks when compared to another published clinical GLP-1 trial that included a daily 500-calorie deficit, 150 minutes of weekly exercise, and in-person counseling every four weeks. Not a head-to-head study. Results may vary. 

Sources: 

  • Gofron, Krzysztof Ksawery, Andrzej Wasilewski, and Sylwia Małgorzewicz. “Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.” Nutrients, vol. 17, no. 8, 2025, article 1303. MDPI, https://doi.org/10.3390/nu17081303. 
  • Jalleh, Ryan J., Chris K. Rayner, Trygve Hausken, Karen L. Jones, Michael Camilleri, and Michael Horowitz. “Gastrointestinal Effects of GLP-1 Receptor Agonists: Mechanisms, Management, and Future Directions.” The Lancet Gastroenterology & Hepatology, vol. 9, no. 10, Oct. 2024, pp. 957–964. ScienceDirect, https://doi.org/10.1016/S2468-1253(24)00188-2. 
  • Cronin, Peter, et al. “Dietary Fibre Modulates the Gut Microbiota.” Nutrients, vol. 13, no. 5, 13 May 2021, article 1655. PubMed, https://doi.org/10.3390/nu13051655. 
  • González, S., et al. “Fermented Dairy Foods: Impact on Intestinal Microbiota and Health-Linked Biomarkers.” Frontiers in Microbiology, vol. 10, article 1046, 24 May 2019, https://doi.org/10.3389/fmicb.2019.01046. 
  • Rodrigues, Vanessa Fernandes, et al. “Akkermansia Muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes.” Frontiers in Immunology, vol. 13, article 934695, 7 July 2022, https://doi.org/10.3389/fimmu.2022.934695. PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC9300896/. 
  • Abdalqadir, Nyan, and Khosrow Adeli. “GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk.” Microorganisms, vol. 10, no. 10, 19 Oct. 2022, article 2061. MDPI, https://doi.org/10.3390/microorganisms10102061. PubMed Central. 
  • Tsai, Chih-Yiu, et al. “Gut Microbial Signatures for Glycemic Responses of GLP-1 Receptor Agonists in Type 2 Diabetic Patients: A Pilot Study.” Frontiers in Endocrinology, vol. 12, article 814770, 10 Jan. 2022. Frontiers, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793908/. 
  • Gofron, Krzysztof Ksawery, et al. “Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.” Nutrients, vol. 17, no. 8, 9 Apr. 2025, article 1303. MDPI, https://doi.org/10.3390/nu17081303. 
  • Cani, Patrice D., and Claude Knauf. “A Newly Identified Protein from Akkermansia muciniphila Stimulates GLP-1 Secretion.” Cell Metabolism, vol. 33, no. 6, 1 June 2021, pp. 1073–1075. Elsevier, https://doi.org/10.1016/j.cmet.2021.05.004. 
  • Gofron, Krzysztof Ksawery, et al. “Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.” Nutrients, vol. 17, no. 8, 9 Apr. 2025, article 1303. MDPI, https://doi.org/10.3390/nu17081303. 
  • Chandwe, Kanta, and Paul Kelly. “Colostrum Therapy for Human Gastrointestinal Health and Disease.” Nutrients, vol. 13, no. 6, 7 June 2021, article 1956. MDPI, https://doi.org/10.3390/nu13061956. 
  • Zhou, QiQi, et al. “Randomised Placebo-Controlled Trial of Dietary Glutamine Supplements for Postinfectious Irritable Bowel Syndrome.” Gut, vol. 68, no. 6, June 2019, pp. 996–1002. BMJ Publishing Group, https://doi.org/10.1136/gutjnl-2017-315136. 
  • Mohseni, Saeid, et al. “Curcumin for the Clinical Treatment of Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Placebo-Controlled Randomized Clinical Trials.” Frontiers in Nutrition, vol. 12, 23 Mar. 2025, article 1494351. Frontiers, https://doi.org/10.3389/fnut.2025.1494351. 
  • Zeng, Xianfeng, et al. “Gut Bacterial Nutrient Preferences Quantified in Vivo.” Cell, vol. 185, no. 18, 1 Sept. 2022, pp. 3441–3456.e19. Elsevier, https://doi.org/10.1016/j.cell.2022.07.020. PubMed Central, PMC9450212. 
  • Sheng, Wei, Guang Ji, and Li Zhang. “Immunomodulatory Effects of Inulin and Its Intestinal Metabolites.” Frontiers in Immunology, vol. 14, 2023, article 1224092. https://doi.org/10.3389/fimmu.2023.1224092. PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC10449545/. 
  • Calame, Wim, et al. “Gum Arabic Establishes Prebiotic Functionality in Healthy Human Volunteers in a Dose-Dependent Manner.” British Journal of Nutrition, vol. 100, no. 6, 2008, pp. 1269–1275. Cambridge University Press, https://doi.org/10.1017/S0007114508981447. 
  • Gofron, Krzysztof Ksawery, et al. “Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.” Nutrients, vol. 17, no. 8, 9 Apr. 2025, p. 1303. MDPI, https://doi.org/10.3390/nu17081303. PubMed Central, PMC12029897. 
  • Zeng, Yuan, Yifan Wu, Qian Zhang, and Xinhua Xiao. “Crosstalk between Glucagon-Like Peptide 1 and Gut Microbiota in Metabolic Diseases.” mBio, vol. 15, no. 1, 6 Dec. 2023, https://doi.org/10.1128/mbio.02032-23. 
  • Zeng, Yuan, Yifan Wu, Qian Zhang, and Xinhua Xiao. “Crosstalk between Glucagon-Like Peptide 1 and Gut Microbiota in Metabolic Diseases.” mBio, vol. 15, no. 1, 6 Dec. 2023, e02032-23. PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC10790698/. 
  • Duncan, Jessica, et al. “Individualized Virtual Integrative Medicine (IVIM): A Clinical Model for Enhanced GLP-1 Therapeutic Outcomes.” Obesity Pillars, vol. 15, 30 June 2025, article 100188. PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC12272120/. 
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